CCKAR

The Cholecystokinin A receptor is a human protein, also known as CCKAR or CCK1. The CCK1R has high affinity for cholecystokinin (CCK) and related peptides that are sulfated on a tyrosine in the 7th position from the COOH terminus with a low affinity for gastrin. In humans, the results of numerous studies support a role for CCK1R in regulation of a variety of physiological processes including gallbladder contraction, sphincter of Oddi relaxation, stimulation of pancreatic secretion, inhibition of acid secretion, relaxation of lower esophageal sphincter tone, slowing of colonic motility and regulation of satiety.

CCKAR Related Products (3):

By Type:	Pan (1)
By Effects:	Agonist (1) Antagonists (2)

Cat. No.	Product Name	Effect	Purity

HY-P1096

A71623	Agonist	99.90%
A71623, a CCK-4-based peptide, is a potent and highly selective CCK-A full agonist. The IC₅₀s for A-71623 are 3.7 nM in guinea pig pancreas (CCK-A) and 4500 nM in cerebral cortex (CCK-B) in radioligand binding assays, respectively.

HY-B2154

Loxiglumide	Antagonist	≥98.0%
Loxiglumide is a cholecystokinin (CCK-1) receptor antagonist.

HY-129810

PD 135158	Antagonist
PD 135158 (CAM 1028) is a selective CCK_B receptor antagonist with an IC₅₀ of 2.8 nM against mouse cortex CCK_B. PD 135158 shows anxiolytic activity.

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